Pair Name | Coptisine, Cisplatin | ||
Phytochemical Name | Coptisine (PubChem CID: 72322 ) | ||
Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
Structure of Phytochemical |
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Coptisine, Cisplatin | |||
Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
Biological Phenomena | Induction-->Blockade of cell cycle in sub-G1 phase | |||
In Vitro Model | NCI-N87 | Gastric tubular adenocarcinoma | Homo sapiens (Human) | CVCL_1603 |
In Vivo Model | One hour after fertilization, zebrafish embryos were selected—only fertilized and completely transparent embryos were transferred to 48 well plates. In each well, at least 3 embryos were kept in the 400 µL of medium without, or supplemented with, different doses of 11 (12.5, 25, 62.5, 125, 187.5 or 250 µg/mL) (39.02, 78.04, 195.12, 390.24, 585.37 or 780.49 µM). | |||
Result | Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells |
No. | Title | Href |
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1 | Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells. Int J Mol Sci. 2022 Sep 7;23(18):10330. doi: 10.3390/ijms231810330. | Click |